AKAP10 and PRKAR2A

Number of citations of the paper that reports this interaction (PubMedID 9326583)
59

Data Source:
HPRD (in vitro)

		AKAP10	PRKAR2A
Description		A-kinase anchoring protein 10	protein kinase cAMP-dependent type II regulatory subunit alpha
Image
GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Protein Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Protein Localization	Intracellular Signal Transduction Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			GEM-231
Diseases
GWAS		Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Mean platelet volume ( 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494 27863252) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)	Apolipoprotein A1 levels ( 33730874) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: IKZF3 PDZK1 PRKAR1A PRKAR2A PRKAR2B RALA SASH1 SLC9A3R1	44 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR FOS GABARAPL2 HYAL1 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1
Entrez ID		11216	5576
HPRD ID		05259	01484
Ensembl ID		ENSG00000108599	ENSG00000114302
Uniprot IDs		A0A0S2Z4Z7 E7EMD6 O43572	A0A024R2W3 A0A0S2Z472 A8KAH7 P13861
PDB IDs		3IM4 3TMH	2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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