AKAP13 and RTKN

Number of citations of the paper that reports this interaction (PubMedID 19696020)
11

Data Source:
BioGRID (pull down)

		AKAP13	RTKN
Description		A-kinase anchoring protein 13	rhotekin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Actin Cytoskeleton Membrane Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm	Cellular_component Actomyosin Contractile Ring Cytosol
	Molecular Function	CAMP-dependent Protein Kinase Activity MAP-kinase Scaffold Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding Molecular Adaptor Activity	GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Nuclear Export Cardiac Muscle Cell Differentiation Regulation Of Sarcomere Organization Bone Development Cell Growth Involved In Cardiac Muscle Cell Development Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body shape index ( 34021172) Central corneal thickness ( 32528159 31798171 29760442 20719862) Corneal structure ( 23291589) Coronary artery disease ( 29212778) Granulocyte percentage of myeloid white cells ( 27863252) Hemoglobin ( 32888494) High myopia ( 32428537) Idiopathic pulmonary fibrosis ( 31710517 29066090) Immature fraction of reticulocytes ( 32888494) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Offspring birth weight ( 31043758) Platelet count ( 32888494) Platelet distribution width ( 32888494) Post-bronchodilator lung function in asthma (FEV1/FVC) ( 32989782) Psoriasis ( 25939698) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to platinum-based chemotherapy (carboplatin) ( 21844884) Systolic blood pressure ( 30578418) Waist circumference adjusted for body mass index ( 34021172)	Refractive error ( 32231278)
Interacting Genes		21 interacting genes: APP CTNNAL1 ESR1 ESR2 GNA12 GNAQ LINC00839 MAP1LC3A PPARA PRKAR2A PRKD1 RANBP2 RHOA RTKN RXRB SRPK2 THRA YWHAB YWHAE YWHAG YWHAZ	11 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOC SMURF1 TAX1BP3 TGFBR1
Entrez ID		11214	6242
HPRD ID		05253	03795
Ensembl ID		ENSG00000170776	ENSG00000114993
Uniprot IDs		A8MYJ1 B0AZU4 Q12802	Q9BST9
PDB IDs		2DRN 2LG1 4D0N 4D0O 6BCA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?