KLK8 and RGS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		KLK8	RGS2
Description		kallikrein related peptidase 8	regulator of G protein signaling 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Serine Protease Inhibitor Complex	Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Proteolysis Memory Cell Death Response To Wounding Negative Regulation Of Myelination Keratinocyte Proliferation Negative Regulation Of Axon Regeneration Neuron Projection Morphogenesis Regulation Of Synapse Organization Synapse Organization	Response To Amphetamine Cell Cycle G Protein-coupled Receptor Signaling Pathway Spermatogenesis Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Neuron Projection Development Negative Regulation Of Translation Ovulation Negative Regulation Of MAP Kinase Activity Negative Regulation Of CAMP-mediated Signaling Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Associated Smooth Muscle Maternal Process Involved In Female Pregnancy Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Glycine Import Across Plasma Membrane
Pathways		Formation of the cornified envelope	G alpha (q) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Coronary artery calcification ( 23870195) Response to quetiapine in schizophrenia ( 29503163)
Interacting Genes		10 interacting genes: CYSRT1 KRT31 KRT34 KRTAP1-1 KRTAP10-3 KRTAP10-8 KRTAP5-9 NBPF19 NOTCH2NLA RGS2	62 interacting genes: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CEP126 CHD3 CIAO1 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EGFR EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KLK8 LIG1 LRFN1 MARCHF6 METTL18 MON1A MTUS2 NINL NIPSNAP1 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 PRKN RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A SUN2 TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		11202	5997
HPRD ID		05733	02917
Ensembl ID		ENSG00000129455	ENSG00000116741
Uniprot IDs		A0A0A0MQY9 O60259	A0A024R939 P41220
PDB IDs		5MS3 5MS4	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?
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