MAP4K5 and IFT88

		MAP4K5	IFT88
Description		mitogen-activated protein kinase kinase kinase kinase 5	intraflagellar transport 88
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Centrosome Centriole Cytosol Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Sperm Flagellum Ciliary Tip Ciliary Base Non-motile Cilium
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity	Protein Binding Kinesin Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Intracellular Signal Transduction	Kidney Development Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly
Pathways			Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)	Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		14 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK IFT88 NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440	17 interacting genes: ALDH8A1 CACNA1C CAPN7 CCDC120 EEF2KMT EML2 FBXO7 ITPKB MAP4K5 MSRB1 PCOTH PDX1 PRRC2A RPGR SAP18 SMARCE1 TRIM24
Entrez ID		11183	8100
HPRD ID		05374	09000
Ensembl ID		ENSG00000012983	ENSG00000032742
Uniprot IDs		B3KWC4 Q9Y4K4	A0A140VJL7 B3KX42 Q13099
PDB IDs
Enriched GO Terms of Interacting Partners?
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