CDC37 and IKZF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CDC37	IKZF3
Description		cell division cycle 37, HSP90 cochaperone	IKAROS family zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Chaperone Complex HSP90-CDC37 Chaperone Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Posttranscriptional Regulation Of Gene Expression Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization	Regulation Of Transcription By RNA Polymerase II Mesoderm Development Response To Bacterium Regulation Of B Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Regulation Of B Cell Differentiation Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)	Acute lymphoblastic leukemia (childhood) ( 29348612) Asthma ( 31959851 31619474 28461288) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Asthma with severe exacerbations ( 32841424) Atopic march ( 26542096) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte counts ( 29403010 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Marginal zone lymphoma or systemic lupus erythematosus ( 31407831) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Pediatric autoimmune diseases ( 26301688) Polycystic ovary syndrome ( 30343302) Primary biliary cholangitis ( 19458352 23000144 20639880 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 27399966 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		179 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BHLHB9 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GAS7 GAS8 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA OGT PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRC SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STK32A STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837	166 interacting genes: ABLIM3 AKAP10 AKAP9 ANKS1A AQP1 ARMC7 ARNT2 ATP6V0D1 ATP6V0D2 ATPAF2 ATXN7L2 BCAS2 BCL2L1 BLK BLZF1 BYSL C1orf109 C1QL1 C2CD6 CABP4 CABP5 CARD9 CATSPER1 CCDC102B CCDC187 CCDC24 CCDC57 CCHCR1 CDC37 CDC7 CDK4 CDKN1A CDKN2D CFAP206 CHCHD2 CHD3 CKS1B CLCNKA COA3 CRBN CRK CRYBA4 DGCR6 DTX2 EFHC1 EGLN3 EMC2 ENKD1 EXOC8 EXOSC5 FAM124B FANCG FANCL FARS2 FBF1 FHL3 FRS3 GEM GOLGA2 GOLGA6A GRAP2 GRB2 HNRNPF HNRNPLL HOXC8 HRAS IKZF1 IKZF4 IKZF5 ING5 KANK2 KAT5 KIF9 KIFC3 KLHL38 KRT19 LDOC1 LENG1 LGALS14 LMO1 LMO2 LMO4 LNX1 LONRF1 MAD2L2 MAGOHB MCM7 MCRS1 MID2 MISP MKRN3 MORN3 MRPL28 MRPL53 MYO15B NATD1 NBR2 NEK6 NFKBID NME7 NOS3 NTAQ1 NUDT16L1 NXT2 OAZ3 OSBPL7 OSGIN1 PCID2 PDZD4 PFDN5 PIK3R1 PIK3R2 PIN1 POLM POLR1C PPP1R16B PPP1R18 PRAC1 PRDM1 PRKAA1 PRKAA2 PRKAB2 PSMA1 PSME3 PSMF1 RAD51D RBBP8 RCOR3 RHOA RNF6 RUNX1 SCNM1 SMARCB1 SMARCD1 SPG21 STAMBPL1 STK16 STK26 STX11 SUMO1 TBC1D22B TCAF1 TCAP TCEANC TCHP TEKT3 TEKT4 TFAP2D TLE5 TOB1 TRAPPC6A TRIM42 TSEN15 TSGA10IP TSSK3 TSTD2 TUBG2 UBE2I USP2 VAT1 VBP1 YES1 ZGPAT ZMYM2 ZNF587 ZNF76
Entrez ID		11140	22806
HPRD ID		05456	05869
Ensembl ID		ENSG00000105401	ENSG00000161405
Uniprot IDs		A0A024R7B7 Q16543	Q9UKT9
PDB IDs		1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE
Enriched GO Terms of Interacting Partners?
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