EMILIN1 and BEX3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		EMILIN1	BEX3
Description		elastin microfibril interfacer 1	brain expressed X-linked 3
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Integrin Alpha4-beta1 Complex Collagen-containing Extracellular Matrix Extracellular Exosome EMILIN Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Identical Protein Binding Integrin Binding Involved In Cell-matrix Adhesion	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding
	Biological Process	Aortic Valve Morphogenesis Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Elastic Fiber Assembly Negative Regulation Of Cell Activation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Macrophage Migration	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Multicellular Organism Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	NADE modulates death signalling
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		30 interacting genes: ABI3 BEX3 BEX5 BFSP1 CDCA8 CENPQ COG7 DYNC1I1 EMILIN2 EPHB4 FBXO28 GNG13 IFT20 LAIR2 LRRIQ1 MIA2 MTMR9 NECAB2 NMI PLAC9 PRKAA2 RABGEF1 RIBC1 SNAPC5 TAB2 TAX1BP1 TSNAX YJU2 ZC2HC1C ZNF655	42 interacting genes: AIMP2 AKAP8L BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO EMILIN1 ENKD1 FSD2 GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417
Entrez ID		11117	27018
HPRD ID		00563	02291
Ensembl ID		ENSG00000138080	ENSG00000166681
Uniprot IDs		Q9Y6C2	Q00994
PDB IDs		2KA3 2OII	1SA6
Enriched GO Terms of Interacting Partners?
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