CHEK1 and BRCA2

Number of citations of the paper that reports this interaction (PubMedID 18317453)
54

Data Source:
BioGRID (enzymatic study)

		CHEK1	BRCA2
Description		checkpoint kinase 1	BRCA2 DNA repair associated
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Condensed Nuclear Chromosome Extracellular Space Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Cytosol Protein-containing Complex Intracellular Membrane-bounded Organelle	Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Centrosome Cytosol Secretory Granule Protein-containing Complex BRCA2-MAGE-D1 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Domain Specific Binding Histone Kinase Activity (H3-T11 Specific) Protein Serine Kinase Activity	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding Protein C-terminus Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Identical Protein Binding Gamma-tubulin Binding
	Biological Process	DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation DNA Replication DNA Repair Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Nucleus Organization Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Peptidyl-threonine Phosphorylation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Regulation Of Cell Population Proliferation Mitotic G2/M Transition Checkpoint Positive Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Centrosome Separation Chromatin-mediated Maintenance Of Transcription Negative Regulation Of G0 To G1 Transition Cellular Response To Mechanical Stimulus Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Apoptotic Process Involved In Development Regulation Of Histone H3-K9 Acetylation	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Oocyte Maturation Inner Cell Mass Cell Proliferation Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication Establishment Of Protein Localization To Telomere Mitotic Recombination-dependent Replication Fork Processing
Pathways		Signaling by SCF-KIT Activation of ATR in response to replication stress Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Transcriptional Regulation by E2F6	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		XL844 Enzastaurin CHIR-124 N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL 2-(cyclohexylamino)benzoic acid 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol 6-MORPHOLIN-4-YL-9H-PURINE 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE Fostamatinib
Diseases
GWAS		Breast cancer (survival) ( 25890600) Squamous cell lung carcinoma ( 28604730)	Apolipoprotein B levels ( 32203549) Basal cell carcinoma ( 31174203) Breast cancer ( 29059683 23535729 23535733) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) LDL cholesterol ( 24097068) LDL cholesterol levels ( 32203549 28334899) Lung cancer ( 28604730 24880342) Lung cancer in ever smokers ( 28604730) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		54 interacting genes: AATF AKT1 APP ATM ATR ATXN3 BCL2L1 BLM BRCA1 BRCA2 CDC25A CDC25B CDC25C CHUK CLSPN CNTN2 CSNK2B CUL1 CUL4A DTL FANCE HSP90AA1 ILKAP LATS2 MAPT MCM6 MCM7 MCPH1 MDM4 NFRKB PDE2A PIGM PRKAA1 PRKDC RAD23A RAD51 RB1 RELA SMAD4 TIMELESS TLK1 TOPBP1 TP53 TP53BP1 TRAF4 UBA1 UBA2 UBB UBE2T USP3 XIAP XPO1 XRCC6 YWHAG	49 interacting genes: ATM ATR BCCIP BRCA1 BUB1B CCNA1 CCNA2 CCND1 CCNE1 CDK1 CDK2 CFAP52 CHEK1 CHEK2 DMC1 DYNC1LI1 DYNC1LI2 EMSY ERCC5 FANCD2 FANCE FANCG FANCI FLNA H2AX HMG20B HNRNPC KAT2B LIMD1 MAGED1 NEDD4 PALB2 PDS5B PLEC PLK1 RAD51 RNASEH2A RPA1 SEM1 SERPINH1 SMAD3 STAT5A TP53 TP53BP1 UQCC1 USP11 USP21 WTIP XPO1
Entrez ID		1111	675
HPRD ID		04356	02554
Ensembl ID		ENSG00000149554	ENSG00000139618
Uniprot IDs		B4DT73 E7EPP6 O14757	P51587
PDB IDs		1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2E9N 2E9O 2E9P 2E9U 2E9V 2GDO 2GHG 2HOG 2HXL 2HXQ 2HY0 2QHM 2QHN 2R0U 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8 2YWP 3F9N 3JVR 3JVS 3NLB 3OT3 3OT8 3PA3 3PA4 3PA5 3TKH 3TKI 3U9N 4FSM 4FSN 4FSQ 4FSR 4FST 4FSU 4FSW 4FSY 4FSZ 4FT0 4FT3 4FT5 4FT7 4FT9 4FTA 4FTC 4FTI 4FTJ 4FTK 4FTL 4FTM 4FTN 4FTO 4FTQ 4FTR 4FTT 4FTU 4GH2 4HYH 4HYI 4JIK 4QYE 4QYF 4QYG 4QYH 4RVK 4RVL 4RVM 5DLS 5F4N 5OOP 5OOR 5OOT 5OP2 5OP4 5OP5 5OP7 5OPB 5OPR 5OPS 5OPU 5OPV 5OQ5 5OQ6 5OQ7 5OQ8 5WI2 6FC8 6FCF 6FCK	1N0W 3EU7 6GY2 6HQU
Enriched GO Terms of Interacting Partners?
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