CHD4 and SMARCA4

Number of citations of the paper that reports this interaction (PubMedID 11003653)
66

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		CHD4	SMARCA4
Description		chromodomain helicase DNA binding protein 4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Coregulator Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Nucleosomal DNA Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding ATP-dependent Chromatin Remodeler Activity	RNA Polymerase I Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Transcription Factor Binding Hydrolase Activity Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS	Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)	Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 32469254 24262325 30104761 33020668) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Inflammatory skin disease ( 25574825) Ischemic stroke ( 29531354) LDL cholesterol ( 21347282) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 33339817 31969989) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 31604244) Response to statins (LDL cholesterol change) ( 31969989) Stroke ( 29531354) Total cholesterol levels ( 33339817)
Interacting Genes		25 interacting genes: ATM ATR CD27 CSNK2A1 EP300 H2AC4 H2BC3 H3-4 H3C1 H4C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1	90 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCL25 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 CYP4F3 E2F6 ESR1 ETS2 FANCA GATA1 GMNN H2AX H2BC21 H3-3A H3C14 H4C6 HMGCL HSF1 HSF4 HSPB1 ICAM5 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MPHOSPH6 MRTFA MYC MYOCD NPPB NR3C1 NR4A2 PABPN1 PALS2 PAX6 PBRM1 PDE4A PHB PRKCSH PTEN RAD23A RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP RPS28 SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 SUMO2 TAF15 TMF1 TP53 VAV1 ZMYND11 ZNF69
Entrez ID		1108	6597
HPRD ID		04472	04459
Ensembl ID		ENSG00000111642	ENSG00000127616
Uniprot IDs		F5GWX5 Q14839	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU	2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2 6LTH 6LTJ 6SY2 6ZS2
Enriched GO Terms of Interacting Partners?
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