HSF2BP and BLK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSF2BP	BLK
Description		heat shock transcription factor 2 binding protein	BLK proto-oncogene, Src family tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome Cytosol	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Transcription By RNA Polymerase II Male Meiosis I Female Meiosis I Spermatogenesis Double-strand Break Repair Involved In Meiotic Recombination	Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Platelet Degranulation Regulation Of B Cell Apoptotic Process Cellular Response To DNA Damage Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Negative Regulation Of B Cell Proliferation Neuron Projection Development Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Intracellular Signal Transduction Regulation Of Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Mast Cell Proliferation Regulation Of Platelet Aggregation Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways			RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophilic esophagitis ( 25017104) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroid peroxidase levels ( 29678681) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Systolic blood pressure ( 30578418)	Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Depression ( 33859377) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fasting insulin ( 34059833) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 33106546 22446962 33772158) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Processed meat consumption ( 32066663) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 33272962 26663301 23053960 26316170 26502338 18204098 21408207 32771030 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 30572963 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		293 interacting genes: ABI2 ABLIM1 ACTN3 ADD1 ANAPC16 ANKRD55 ANKS1B ARHGAP45 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ATXN7L2 BARD1 BAX BAZ2B BCAS2 BEND7 BEX2 BLK BMI1 BYSL C10orf88 C18orf54 C1orf35 C1orf94 C2CD6 C4orf46 C5orf49 C7orf31 C9orf24 CAMSAP3 CARD9 CASS4 CBX8 CBY2 CCDC113 CCDC116 CCDC120 CCDC13 CCDC146 CCDC185 CCDC187 CCDC198 CCDC33 CCHCR1 CCSER1 CDC37 CDC73 CDCA7L CDR2L CDYL2 CEP55 CEP57 CKS1B CLIP4 CNNM1 CNNM3 CNOT2 COIL CTSZ CTTNBP2 CTTNBP2NL CWF19L2 DALRD3 DCDC2B DEFB112 DMAP1 DMRT3 DOCK8 DPF2 DUSP13 EAF1 EIF3D ELOA2 EMD ENKD1 EPHB3 EPM2AIP1 FAM107A FAM110A FAM110B FAM124B FAM161B FAM214B FAM228A FAM90A1 FBXO44 FHL2 FHL3 FLYWCH1 FUT9 GAS2L2 GAS8 GCM2 GEM GGN GNL3L GOLGA1 GPANK1 GPATCH2L GPBP1 GPKOW GPSM3 H2AW HASPIN HCK HDAC4 HEXIM2 HEY2 HNRNPH2 HOMEZ HOXB5 HOXC8 HSF2 IER2 IL16 INO80B INPP5J INSYN2A IPMK IQCC ITGB3BP JRK KANK2 KAT5 KIAA0408 KIF24 KIF5B KIF9 KIFC3 KLF4 L3MBTL2 L3MBTL3 L3MBTL4 LAGE3 LEP LGALS4 LMO4 LNX1 LRRC29 LRRC56 LRRN4 LUZP4 MAGED1 MAGOHB MARCHF7 MEF2A MFAP1 MISP MKRN3 MVB12A MYOZ3 NAB2 NCK2 NFIL3 NHSL2 NME4 NPPA NSMF NTAQ1 NUDT10 NXF1 ODF3B ODF3L2 OPTN P2RX7 PAK6 PAPSS2 PARD6B PDLIM7 PICK1 PKD2 PKN1 PKP1 PLB1 PLEKHA2 PLEKHA7 PNMA5 POGZ POLDIP3 POMC PPM1K PPP1R18 PPP1R32 PRPF18 PRPF3 PRPF31 PRR5L PSMA1 PSTPIP1 RAB11FIP2 RAB36 RAB3IL1 RAD51D RALY RBM17 RBM41 RBM48 RCOR3 REXO4 RIBC1 RIN1 RNF135 RNF169 ROBO3 RPS28 RTP5 SAMD4A SAPCD1 SART1 SAXO1 SCNM1 SDCBP SELENOV SEMA3B SEMA4C SEPTIN1 SEPTIN9 SETDB1 SH2D4A SHFL SHISA6 SIRPA SLAIN1 SLC6A1 SMARCB1 SMARCD1 SMG9 SNAPC1 SNW1 SNX18 SNX21 SPATA22 SPEG SPG7 SPRED1 SPRY1 SYCE1L SYNGAP1 TAB2 TAGAP TASOR2 TBC1D1 TBC1D30 TCEA2 TCF19 TEPSIN TFIP11 THAP6 TMEFF2 TMSB4X TNS4 TOX2 TP53BP2 TRAF5 TRARG1 TSEN15 TSGA10IP TSHZ3 TTC23 TTC9C TULP3 UBE2I UPF2 UPRT USP20 VEZF1 VHL VPS72 WASF1 WASHC1 WDR25 YJU2B ZBTB16 ZBTB42 ZC2HC1C ZCWPW2 ZFC3H1 ZGPAT ZNF185 ZNF250 ZNF417 ZNF511 ZNF564 ZNF581 ZNF587 ZNF648 ZNF688 ZNF774 ZNF835 ZNF84 ZNF844	56 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR EGR3 ERBB2 ERBB3 ERBB4 FAM167A FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 MTMR9 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS1 SOCS3 SPAG11B SSBP3 STAP2 STAT3 TDP2 TFAP2C UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774
Entrez ID		11077	640
HPRD ID		05186	01866
Ensembl ID		ENSG00000160207	ENSG00000136573
Uniprot IDs		O75031 Q6IAT7	E9PJX5 P51451 Q05D26
PDB IDs
Enriched GO Terms of Interacting Partners?
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