WWP2 and NUTF2

		WWP2	NUTF2
Description		WW domain containing E3 ubiquitin protein ligase 2	nuclear transport factor 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Membrane Extracellular Exosome	Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytosol Nuclear Membrane Nuclear Pore Central Transport Channel Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	Protein Binding Structural Constituent Of Nuclear Pore Small GTPase Binding Identical Protein Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Cellular Protein Modification Process Extracellular Transport Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity	Protein Import Into Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Positive Regulation Of Protein Import Into Nucleus MRNA Transport Protein Localization To Nuclear Pore Negative Regulation Of Vascular Endothelial Growth Factor Production
Pathways		Regulation of PTEN stability and activity RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 28552196 31562340) IgE levels ( 23146381) Knee osteoarthritis ( 30374069) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FVC) ( 30804560) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Menarche (age at onset) ( 25231870) Myocardial infarction ( 33532862) Plantar fascial disorders ( 29534260) Platelet count ( 32888494) Pulse pressure ( 30578418) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 33082346) Triglyceride levels ( 31928498) Triglycerides ( 30275531) Waist circumference ( 31928498)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		82 interacting genes: ANKRD44 ARRDC1 ARRDC3 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EFCAB3 EGR2 EWSR1 FAM189A2 FAM214B FBXL18 GADD45GIP1 GAS2L2 GGN GRAP2 HNRNPUL1 IFIT2 IL2RG IL6R LGALS9B MED25 MIR19A MIR19B1 MIR92A1 NDFIP1 NDFIP2 NOTCH4 NUTF2 PAIP1 PATZ1 PDLIM7 PLA2G15 PRKAA2 PSMF1 RASA1 RASD1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SEC24D SF1 SFTPC SLC9A3R2 SMAD3 SMAD7 SMARCD1 SMR3A SNRPB SNRPC SPART TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2J2 UBE2K UBE2L3 UBTD1 USP7 VASP VPS37C WBP1 WBP2 WDR5 WIPF1 ZNF688	55 interacting genes: BEND7 BRWD1 CAMK2G CANX CCDC106 CCDC150 CCDC158 CHCHD3 CHMP4A CKMT1A CKMT1B CLPP FAM50B GLRX2 HMG20A HMG20B KHDC4 KPNB1 KRT86 KRTAP9-8 LASP1 LCE1C LCE5A LENG1 LUC7L2 MRNIP MYOZ3 NFAT5 NME1 NME4 NRIP3 NUP153 NUP54 NUP62 PAX4 PBX4 PCNA PFKP PHF11 PPP1R16A PTMA RAN RPRD1B SF3B3 SPATC1L SPRY4 TERF2 TEX35 THAP11 THAP3 TLE5 UBAP2 WWP2 YAF2 ZMAT2
Entrez ID		11060	10204
HPRD ID		03812	12050
Ensembl ID		ENSG00000198373	ENSG00000102898
Uniprot IDs		A0A024R711 B4DHF6 O00308	A0A024R6Y2 P61970
PDB IDs		4Y07 5TJ7 5TJ8 5TJQ 6J1Z 6RSS	1GY5
Enriched GO Terms of Interacting Partners?
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