WWP1 and FBXL18

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		WWP1	FBXL18
Description		WW domain containing E3 ubiquitin protein ligase 1	F-box and leucine rich repeat protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) High light scatter reticulocyte count ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Relative hand skill in reading disability ( 24068947)
Interacting Genes		58 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 DVL2 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		11059	80028
HPRD ID		03811	07753
Ensembl ID		ENSG00000123124	ENSG00000155034
Uniprot IDs		Q9H0M0	A0A024R857 B4DH63 Q96D16
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y
Enriched GO Terms of Interacting Partners?
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