RCC1 and PDHB

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RCC1	PDHB
Description		regulator of chromosome condensation 1	pyruvate dehydrogenase E1 subunit beta
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GO Annotations	Cellular Component	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Membrane Protein-containing Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Chromatin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Nucleosome Binding Nucleosomal DNA Binding Histone Binding Sulfate Binding Protein Heterodimerization Activity	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Membrane Reassembly Regulation Of Mitotic Nuclear Division Viral Process Regulation Of Catalytic Activity Spindle Assembly Cell Division	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Rev-mediated nuclear export of HIV RNA Nuclear import of Rev protein Postmitotic nuclear pore complex (NPC) reformation	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs			Pyruvic acid NADH
Diseases
GWAS		Night sleep phenotypes ( 27126917) Systolic blood pressure ( 30578418)	Apolipoprotein B levels ( 32203549) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) IgG levels ( 28628107) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Systemic lupus erythematosus ( 26502338 28714469) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) vWF levels ( 30586737)
Interacting Genes		51 interacting genes: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 ERCC6 FAF1 FBXO7 FLAD1 GNB2 H2AC18 H2AC20 H2BC21 H3C1 HADHB HMGA1 HOXD8 KMT2B KPNA3 KPNA4 LRIF1 NGFR NTMT1 NUDT21 NUP98 OGT PDHB PKM PTMA RAN RANBP1 RANBP3 RPA1 SDF4 SPRED1 SUMO2 TLE1 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135	19 interacting genes: ADORA2A AKT1 ANXA7 ATXN7 CDKN1A FCER1A GNB2 GRB7 HSD17B10 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 SHANK3 TRIM63 TSC22D1
Entrez ID		1104	5162
HPRD ID		01559	01530
Ensembl ID		ENSG00000180198	ENSG00000168291
Uniprot IDs		A0A0S2Z3I4 A0A0S2Z404 P18754 Q5T081	A0A384MDR8 P11177
PDB IDs		1A12 1I2M 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 5TBK 6DUB	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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