SRSF8 and CLK3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SRSF8	CLK3
Description		serine and arginine rich splicing factor 8	CDC like kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs			K-00546 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Chronic widespread musculoskeletal pain ( 33331911)	Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712)
Interacting Genes		8 interacting genes: APP CLK3 KRTAP12-2 SREK1 SRPK1 SRPK2 SRSF3 TRA2B	41 interacting genes: APP CHERP CLASRP CLK2 DDIT4L HOXB6 HOXB7 HOXC4 INCA1 KRTAP10-3 LNX1 NEDD4 NKAPL NXF1 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RNF8 RNPS1 RSRP1 SAG SDCBP SH2B2 SLAMF7 SNIP1 SNRNP35 SRPK2 SRSF10 SRSF3 SRSF8 SUV39H1 TINF2 TRA2B USP13 YWHAG ZNF263 ZNF473 ZNF777 ZNF835
Entrez ID		10929	1198
HPRD ID		04466	04290
Ensembl ID		ENSG00000263465	ENSG00000179335
Uniprot IDs		A0A024R3A8 Q9BRL6	B3KRI8 P49761
PDB IDs		2DNM	2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT 6YTW 6YTY 6YU1 6Z2V 6Z51 6Z52 6Z53 6Z54 6Z55
Enriched GO Terms of Interacting Partners?
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