DBF4 and MCM3

Number of citations of the paper that reports this interaction (PubMedID 12614612)
25

Data Source:
HPRD (two hybrid)

		DBF4	MCM3
Description		DBF4 zinc finger	minichromosome maintenance complex component 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Centrosome Membrane MCM Complex Perinuclear Region Of Cytoplasm CMG Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity	DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition	Double-strand Break Repair Via Break-induced Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding Mitotic DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Cryptococcosis in HIV infection ( 33269293)
Interacting Genes		18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	37 interacting genes: CCNE1 CDC45 CDC5L CDC6 CDC7 CDK2 CSNK2A1 DBF4 EP300 HAUS1 KEAP1 LZTR1 MAPK6 MCM10 MCM2 MCM3AP MCM4 MCM5 MCM6 MCM7 MCMBP ORC2 ORC4 ORC5 PLK1 POLR2A PPP2R1A PPP2R1B PTEN RAD52 STAT1 SUMO2 SUPT16H SYF2 TFAP2B TRIM28 YWHAQ
Entrez ID		10926	4172
HPRD ID		10371	04072
Ensembl ID		ENSG00000006634	ENSG00000112118
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	A0A0S2Z4T1 A0A499FHX9 B4DUQ9 P25205
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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