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LYVE1 and PDGFB
Number of citations of the paper that reports this interaction (PubMedID
7829517
)
6
Data Source:
BioGRID
(pull down)
LYVE1
PDGFB
Description
lymphatic vessel endothelial hyaluronan receptor 1
platelet derived growth factor subunit B
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Extracellular Exosome
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Basolateral Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
Hyaluronic Acid Binding
Signaling Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Platelet-derived Growth Factor Binding
Growth Factor Receptor Binding
Biological Process
Glycosaminoglycan Catabolic Process
Cell-matrix Adhesion
Response To Wounding
Anatomical Structure Morphogenesis
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Activation Of Protein Kinase B Activity
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Positive Regulation Of Cell Division
Cell Chemotaxis
Positive Regulation Of Protein Tyrosine Kinase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase C Signaling
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways
Hyaluronan uptake and degradation
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Pegpleranib
Diseases
GWAS
Blood protein levels (
30072576
)
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Interacting Genes
26 interacting genes:
AIG1
AQP10
CLCN7
CYSRT1
EMP3
KRT34
KRTAP10-3
KRTAP10-8
KRTAP12-3
KRTAP6-2
KRTAP9-2
NBPF19
NINJ2
NOTCH2NLA
NRSN1
PDGFB
PIGF
SERP2
SLC30A2
SLC38A7
SLC41A2
THSD7A
THSD7B
UBE2J1
VEGFA
YIPF6
26 interacting genes:
A2M
ART1
BCCIP
CLCN3
COL15A1
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HMOX1
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
Entrez ID
10894
5155
HPRD ID
05753
01815
Ensembl ID
ENSG00000133800
ENSG00000100311
Uniprot IDs
B2R672
Q9Y5Y7
A0A384NYY3
P01127
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
6T9E
Enriched GO Terms of Interacting Partners
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