WASF3 and RASAL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		WASF3	RASAL3
Description		WASP family member 3	RAS protein activator like 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Cell Cortex Membrane Extracellular Exosome Cytoplasmic Side Of Membrane
	Molecular Function	Actin Binding Protein Kinase A Regulatory Subunit Binding Arp2/3 Complex Binding	GTPase Activator Activity Protein Binding Identical Protein Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Oligodendrocyte Development Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Positive Regulation Of Myelination Protein-containing Complex Assembly Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Signal Transduction Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of NK T Cell Proliferation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of RAS by GAPs
Drugs
Diseases
GWAS		Hallux valgus ( 32131869) Left-handedness ( 32989287) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Sporadic pituitary adenoma ( 26029870) Systolic blood pressure ( 30224653)	Blood protein levels ( 29875488) Lymphocyte counts ( 32888494)
Interacting Genes		12 interacting genes: ABI2 ACTB ACTR3 BYSL CAMK2D CKS1B EGFR KANK2 KIFC3 PIK3R1 PIK3R2 RASAL3	24 interacting genes: AKAP8L AMOTL2 BEGAIN CCDC102B CCDC136 CDR2L DEF6 HNRNPK HOMER1 KHDRBS3 KRT27 MTUS2 NTAQ1 PICK1 PPP1R13B PRKAA2 RABGEF1 RASD1 SNRPA TP53BP2 WASF3 YWHAE YWHAZ ZRANB1
Entrez ID		10810	64926
HPRD ID		05458	10977
Ensembl ID		ENSG00000132970	ENSG00000105122
Uniprot IDs		Q5T8P4 Q9UPY6	Q86YV0
PDB IDs
Enriched GO Terms of Interacting Partners?
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