IQGAP2 and RHOG

Number of citations of the paper that reports this interaction (PubMedID 12376551)
57

Data Source:
HPRD (in vitro)

		IQGAP2	RHOG
Description		IQ motif containing GTPase activating protein 2	ras homolog family member G
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome	Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Extracellular Exosome
	Molecular Function	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Catalytic Activity Regulation Of GTPase Activity Thrombin-activated Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		RHO GTPases activate IQGAPs Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle	GPVI-mediated activation cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOG GTPase cycle
Drugs
Diseases
GWAS		Body shape index ( 34021172) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG	21 interacting genes: ARHGDIA ARHGDIG CCR2 DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 ERCC6 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		10788	391
HPRD ID		09253	01537
Ensembl ID		ENSG00000145703	ENSG00000177105
Uniprot IDs		B7Z7U6 B7Z7X2 Q13576 Q59HA3	P84095 Q6ICQ8
PDB IDs		3IEZ 4EZA 5CJP	6UKA
Enriched GO Terms of Interacting Partners?
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