MAP3K2 and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 12912994)
26

Data Source:
HPRD (in vitro, in vivo)

		MAP3K2	MAP3K5
Description		mitogen-activated protein kinase kinase kinase 2	mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytoplasm Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	MAPK Cascade Response To Ischemia Protein Phosphorylation JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Wound Healing Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways			Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)	Eosinophil counts ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	65 interacting genes: AKT1 ARRB2 AURKA CCND2 CDC25A CDK4 CDK6 CDKN1A CDKN2A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 KIAA0408 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		10746	4217
HPRD ID		10068	03904
Ensembl ID		ENSG00000169967	ENSG00000197442
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q99683
PDB IDs		2CU1 2NPT 5EX0 5HQ8	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH
Enriched GO Terms of Interacting Partners?
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