CTCF and CHD8

Number of citations of the paper that reports this interaction (PubMedID 16949368)
126

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CTCF	CHD8
Description		CCCTC-binding factor	chromodomain helicase DNA binding protein 8
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Protein-containing Complex MLL1 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA ATP Hydrolysis Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Chromosome Segregation Negative Regulation Of Cell Population Proliferation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genetic Imprinting	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Remodeling Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)	Height ( 31562340) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CHD1L CHD7 CHD8 DHX38 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	11 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 SUMO2 TOP3B WDR5
Entrez ID		10664	57680
HPRD ID		05005	16712
Ensembl ID		ENSG00000102974	ENSG00000100888
Uniprot IDs		A0A2R8YFL0 P49711	Q9HCK8
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX	2CKA 2DL6
Enriched GO Terms of Interacting Partners?
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