CELF1 and DMPK

Number of citations of the paper that reports this interaction (PubMedID 9371827)
48

Data Source:
HPRD (in vitro)

		CELF1	DMPK
Description		CUGBP Elav-like family member 1	DM1 protein kinase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Perinucleolar Compartment Ribonucleoprotein Complex	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Translation Initiation Factor Binding Pre-mRNA Binding BRE Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing Germ Cell Development Spermatid Development Negative Regulation Of Cell Population Proliferation Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell Death RNA Interference Posttranscriptional Gene Silencing Cerebral Cortex Development Positive Regulation Of Multicellular Organism Growth Regulation Of RNA Splicing Regulation Of Inflammatory Response Regulation Of Cell Cycle MRNA Destabilization	Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Catalytic Activity
Pathways			Ion homeostasis
Drugs			Bisindolylmaleimide VIII
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Hand grip strength ( 29691431) Immature fraction of reticulocytes ( 32888494 27863252) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolic syndrome ( 31589552) Neuroticism ( 29255261) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Platelet count ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Sleep duration (short sleep) ( 30846698) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969) Youthful appearance (self-reported) ( 32339537)	Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597)
Interacting Genes		47 interacting genes: APP DMPK FUBP1 MIR106B MIR107 MIR10B MIR128-1 MIR138-2 MIR140 MIR143 MIR155 MIR15B MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR25 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR363 MIR7-1 MIR7-2 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I OGT PPBP RALY TOM1L1	19 interacting genes: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A PVR RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		10658	1760
HPRD ID		03046	05645
Ensembl ID		ENSG00000149187	ENSG00000104936
Uniprot IDs		G5EA30 Q92879	B4DM55 B4DZE2 E5KR05 E5KR06 E5KR07 I6L989 Q09013
PDB IDs		2CPZ 2DHS 2RQ4 2RQC 3NMR 3NNA 3NNC 3NNH	1WT6 2VD5
Enriched GO Terms of Interacting Partners?
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