CENPF and IRF6

		CENPF	IRF6
Description		centromere protein F	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Protein Homodimerization Activity Dynein Complex Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Muscle Organ Development Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly DNA Biosynthetic Process	Immune System Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Cell Cycle Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Cranial Skeletal System Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360) Serum immune biomarker levels ( 32066700)	Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)
Interacting Genes		16 interacting genes: BRAP CENPE CHMP2B FNTA FNTB HSD11B1 IRF6 KLHL41 NDEL1 NUP133 PLOD2 SLC30A1 SLC4A1AP SNAP25 SVIL TOP3B	5 interacting genes: CENPF IRF8 RFX3 TLX2 ZBTB3
Entrez ID		1063	3664
HPRD ID		02582	06227
Ensembl ID		ENSG00000117724	ENSG00000117595
Uniprot IDs		P49454	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?
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