TXNIP and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 31669268)
4

Data Source:
BioGRID (two hybrid)

		TXNIP	SIVA1
Description		thioredoxin interacting protein	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleoplasm Cytoplasm
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Cell Cycle Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		28 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT ZBTB16 ZBTB32	32 interacting genes: ABL2 APP AQP1 BAG5 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446
Entrez ID		10628	10572
HPRD ID		05964	16124
Ensembl ID		ENSG00000265972	ENSG00000184990
Uniprot IDs		Q9H3M7	O15304
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?
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