STAMBP and CYP2C9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		STAMBP	CYP2C9
Description		STAM binding protein	cytochrome P450 family 2 subfamily C member 9
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Arachidonic Acid 14,15-epoxygenase Activity Arachidonic Acid 11,12-epoxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity Aromatase Activity
	Biological Process	Mitotic Cytokinesis Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Amide Metabolic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway
Pathways		Metalloprotease DUBs	Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs
Drugs			Ferroheme C Diacerein Benzbromarone
Diseases
GWAS		Anti-saccade response ( 29064472) Bell's palsy ( 33602968) Blood metabolite levels ( 26401656) Serum metabolite levels ( 33031748 23093944)	Blood metabolite levels ( 24816252) Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) glucocorticoid receptor gene expression in B-cell precursor acute lymphoblastic leukaemia ( 33002292) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)
Interacting Genes		46 interacting genes: ALAS1 AMN APOBEC3A BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP3 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S ULK1 USP21 USP28	10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A
Entrez ID		10617	1559
HPRD ID		05877	03084
Ensembl ID		ENSG00000124356	ENSG00000138109
Uniprot IDs		A0A140VK54 O95630	P11712 S5RV20
PDB IDs		2XZE 3RZU 3RZV 5IXF	1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT
Enriched GO Terms of Interacting Partners?
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