SPAG5 and ORC6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SPAG5	ORC6
Description		sperm associated antigen 5	origin recognition complex subunit 6
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Cytoplasm Cytosol Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole	Origin Recognition Complex Fibrillar Center Nucleoplasm Nuclear Origin Of Replication Recognition Complex Membrane
	Molecular Function	Protein Binding Microtubule Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly	DNA Replication Initiation Negative Regulation Of Cell Division
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Interacting Genes		58 interacting genes: AMOTL2 ARNT2 ATN1 BARD1 C1orf109 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688	19 interacting genes: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2
Entrez ID		10615	23594
HPRD ID		10246	06237
Ensembl ID		ENSG00000076382	ENSG00000091651
Uniprot IDs		Q96R06	A0A024R6R3 Q9Y5N6
PDB IDs			3M03 6KVG
Enriched GO Terms of Interacting Partners?
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