MXD4 and SMC3

Number of citations of the paper that reports this interaction (PubMedID 9528857)
6

Data Source:
BioGRID (two hybrid, pull down)

		MXD4	SMC3
Description		MAX dimerization protein 4	structural maintenance of chromosomes 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Mitotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	Chromatin Binding Double-stranded DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Cohesin Loading Activity Dynein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Mitotic Spindle Assembly
Pathways		Nuclear signaling by ERBB4	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Monocyte count ( 32888494)	Acute respiratory distress syndrome in sepsis ( 31982041) Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: MAX MLX SHBG SIN3A SMC3 TCP10L	19 interacting genes: APC CEP63 CYP27B1 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B SUMO2 TRAF3IP1
Entrez ID		10608	9126
HPRD ID		10103	05829
Ensembl ID		ENSG00000123933	ENSG00000108055
Uniprot IDs		Q14582	Q9UQE7
PDB IDs			6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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