CENPC and MDC1

Number of citations of the paper that reports this interaction (PubMedID 14578343)
91

Data Source:
BioGRID (unspecified method)

		CENPC	MDC1
Description		centromere protein C	mediator of DNA damage checkpoint 1
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome, Centromeric Region Nucleoplasm Pericentric Heterochromatin Cytosol Nuclear Body Midbody	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding	Protein Binding Protein C-terminus Binding FHA Domain Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Monopolar Spindle Attachment To Meiosis I Kinetochore	DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Walking pace ( 33128006)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		7 interacting genes: DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF	41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		1060	9656
HPRD ID		00315	16252
Ensembl ID		ENSG00000145241	ENSG00000137337
Uniprot IDs		Q03188	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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