MTHFS and TSC22D4

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1103

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MTHFS	TSC22D4
Description		methenyltetrahydrofolate synthetase	TSC22 domain family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nucleus
	Molecular Function	ATP Binding Folic Acid Binding 5-formyltetrahydrofolate Cyclo-ligase Activity Metal Ion Binding	Protein Binding
	Biological Process	Glutamate Metabolic Process Folic Acid-containing Compound Biosynthetic Process Formate Metabolic Process Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Folic Acid Catabolic Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways		Metabolism of folate and pterines
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576 29875488) Cerebrospinal P-tau181p levels ( 28247064) Circulating leptin levels in high cardiovascular risk ( 31766143) Diabetic retinopathy in type 2 diabetes ( 33607655) Disease-free survival in breast cancer ( 25867717) Pars opercularis volume ( 31530798) Periodontitis (Mean PAL) ( 24024966) Response to fenofibrate (LDL cholesterol levels) ( 27002377)	Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: TSC22D4	63 interacting genes: ABLIM1 AIFM1 APIP ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		10588	81628
HPRD ID		09174	18231
Ensembl ID		ENSG00000136371	ENSG00000166925
Uniprot IDs		P49914	B4DKI8 Q9Y3Q8
PDB IDs		3HXT 3HY3 3HY4 3HY6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?