SORBS1 and MAP4K3

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		SORBS1	MAP4K3
Description		sorbin and SH3 domain containing 1	mitogen-activated protein kinase kinase kinase kinase 3
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GO Annotations	Cellular Component	Stress Fiber Nucleus Centrosome Cytosol Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft
	Molecular Function	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity
	Biological Process	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane	Protein Phosphorylation JNK Cascade Response To UV Response To Tumor Necrosis Factor Intracellular Signal Transduction
Pathways		Smooth Muscle Contraction
Drugs			Fostamatinib
Diseases
GWAS		Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)	Bone mineral density ( 31790847)
Interacting Genes		27 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	8 interacting genes: BIN1 COPS5 GRB2 HNRNPLL ITSN2 SH3GL2 SH3RF1 SORBS1
Entrez ID		10580	8491
HPRD ID		05587	05373
Ensembl ID		ENSG00000095637	ENSG00000011566
Uniprot IDs		B4DTX5 Q9BX66	A8K602 B3KMM5 Q8IVH8
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP	5J5T
Enriched GO Terms of Interacting Partners?
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