TADA3 and HSPA8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TADA3	HSPA8
Description		transcriptional adaptor 3	heat shock protein family A (Hsp70) member 8
Image		No pdb structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex Mitotic Spindle	Prp19 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Lysosome Lysosomal Membrane Late Endosome Autophagosome Cytosol Plasma Membrane Focal Adhesion Membrane Dendrite Secretory Granule Lumen Melanosome Terminal Bouton Lysosomal Lumen Perinuclear Region Of Cytoplasm Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Extracellular Exosome Blood Microparticle Lumenal Side Of Lysosomal Membrane Photoreceptor Ribbon Synapse Glycinergic Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol Postsynaptic Specialization Membrane Chaperone Complex Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Nuclear Receptor Coactivator Activity	G Protein-coupled Receptor Binding Phosphatidylserine Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding MHC Class II Protein Complex Binding Protein-macromolecule Adaptor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Protein Disaggregase Activity Protein Carrier Activity Clathrin-uncoating ATPase Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Regulation Of Histone Deacetylation Regulation Of Protein Stability Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Regulation Of Tubulin Deacetylation	MRNA Processing Protein Folding Response To Unfolded Protein RNA Splicing Cellular Response To Starvation Vesicle-mediated Transport Regulation Of Protein Stability Cellular Response To Unfolded Protein Protein Refolding Regulation Of Protein-containing Complex Assembly Positive Regulation By Host Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Chaperone Cofactor-dependent Protein Refolding Regulation Of Cell Cycle Membrane Organization Regulation Of Protein Complex Stability Chaperone-mediated Autophagy Late Endosomal Microautophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Regulation Of Postsynapse Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Protein Import Chaperone-mediated Autophagy Translocation Complex Disassembly Slow Axonal Transport
Pathways		HATs acetylate histones Ub-specific processing proteases	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy
Drugs			Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494) Postoperative acute renal failure after cardiac surgery ( 30678657) Red cell distribution width ( 32888494) Serum metabolite levels ( 33031748)
Interacting Genes		33 interacting genes: ADPGK ANKRD12 ANKRD36B AR CCNC EIF3J EP300 ESR1 FAM107B H3-4 HEXIM2 HSPA8 ING5 KDM1A MAGEH1 MFHAS1 NR1I2 OGT PIAS4 RARA RFX1 RXRA RXRB SAP18 SGF29 STX11 TADA2A TP53 TXLNB TXNRD2 USP5 XRCC6 ZNF7	91 interacting genes: ABI1 AIPL1 ALDOB APOB ATM BAG1 BAG2 BAG3 BAG4 BAG6 BRCA1 CAPZA1 CAPZB CCT3 CD40 CDKN2A CITED1 CLTA COL7A1 CXCR4 CYCS DNAJA1 DNAJA3 DPP3 DYNLL1 EGFR ENO1 ERBB3 ERH ESR1 FANCC FBP1 GAK GCH1 GOT2 H3C1 HDAC10 HDAC3 HGS HLTF HSF1 HSP90AA1 HSPA1A HSPBP1 HSPH1 HTN3 HTT IL32 JAK2 JUN LALBA LINC01554 MAPK8 MAPT METTL21A NMI NOA1 OGT PHC1 PPID PTEN PTPRF RAF1 RB1 REL RGS2 SGTA SIRPA SP1 SRRT ST13 STAT1 STIP1 STMN1 STUB1 SUMO2 SUMO4 TADA3 TCAP TCERG1 TGM2 TM4SF1 TNFRSF1A TRIM38 TSSK6 TTC1 UBC UCHL1 VHL YWHAG YWHAQ
Entrez ID		10474	3312
HPRD ID		04252	07205
Ensembl ID		ENSG00000171148	ENSG00000109971
Uniprot IDs		A0A024R2D7 A8K899 O75528	P11142 Q53HF2 V9HW22
PDB IDs			3AGY 3AGZ 3ESK 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 4H5N 4H5R 4H5T 4H5V 4H5W 4HWI 4KBQ 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV 6B1I 6B1M 6B1N 6ZYJ
Enriched GO Terms of Interacting Partners?
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