FST and CATSPER1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FST	CATSPER1
Description		follistatin	cation channel sperm associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm	Plasma Membrane Motile Cilium CatSper Complex
	Molecular Function	Protein Binding Activin Receptor Antagonist Activity Heparan Sulfate Proteoglycan Binding Activin Binding	Calcium Activated Cation Channel Activity Voltage-gated Calcium Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Hematopoietic Progenitor Cell Differentiation Multicellular Organism Development Gamete Generation Pattern Specification Process Female Gonad Development Cell Differentiation BMP Signaling Pathway Regulation Of BMP Signaling Pathway Hair Follicle Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Keratinocyte Proliferation Negative Regulation Of Cell Differentiation Positive Regulation Of Hair Follicle Development	Calcium Ion Transport Spermatogenesis Cell Differentiation Flagellated Sperm Motility Regulation Of Ion Transmembrane Transport Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Calcium Ion Transmembrane Transport
Pathways		Antagonism of Activin by Follistatin	Sperm Motility And Taxes
Drugs		D-Myo-Inositol-Hexasulphate
Diseases
GWAS		Acne (severe) ( 24927181 30542056) Alzheimer's disease (late onset) ( 30820047) Central corneal thickness ( 32528159) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Height ( 31562340) High-grade serous ovarian cancer ( 31469419) Intraocular pressure ( 29617998 29235454) Keratoconus ( 33649486) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Midgestational circulating levels of PCBs ( 28235828) Optic disc size ( 31809533) Refractive error ( 32231278) Vaginal microbiome composition (community state type) ( 32723796)	Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340)
Interacting Genes		14 interacting genes: BEX2 BMP5 C8orf33 CATSPER1 CREB5 FN1 HOXA1 INHA INHBA INHBE MEST TK1 TXN ZNF587	116 interacting genes: ABLIM3 ADAMTSL4 AGR2 AGR3 AJUBA AKAP8L APOA2 ARID5A BEGAIN C11orf1 C11orf16 C9orf24 CARD10 CDPF1 CHIC2 CHRD CPSF7 CTBP2 CYSRT1 EFEMP2 EMD EYA2 FHL5 FRS3 FST GLI1 HNRNPH1 HOXA1 IKZF3 KHDRBS2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1D LCE1E LCE1F LCE2C LIMS1 LZTS2 MDFI MTUS2 MYCL NBPF19 NOTCH2NLA PAK5 PDLIM7 PLA2G10 PLAGL2 PLSCR1 PLSCR3 PMF1-BGLAP PPP1R32 PTPN21 RFX6 RGS19 RGS20 RIMBP3 RSPO2 SCRG1 SIVA1 SORBS3 SPRY2 SPRY3 SSC4D TGFB1 TNS2 TRAF2 TRIM27 TRIM42 TRIM8 TRIP6 TSPAN4 VWC2 ZBTB42 ZIM2 ZNF688 ZNF774 ZNF837
Entrez ID		10468	117144
HPRD ID		00641	09396
Ensembl ID		ENSG00000134363	ENSG00000175294
Uniprot IDs		A0A024QZU6 P19883	Q8NEC5
PDB IDs		2B0U 2P6A 3HH2 5JHW
Enriched GO Terms of Interacting Partners?
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