RBM14 and RUNX1

Number of citations of the paper that reports this interaction (PubMedID 19585539)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RBM14	RUNX1
Description		RNA binding motif protein 14	RUNX family transcription factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Nuclear Speck Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding MRNA Binding Protein Binding Nuclear Receptor Coactivator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding ATP Binding
	Biological Process	MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Response To Hormone Histone Deacetylation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication SMAD Protein Signal Transduction Centriole Assembly	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Myeloid Leukocyte Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Plasminogen Activation Hemopoiesis Neuron Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement
Pathways		RUNX2 regulates bone development	Pre-NOTCH Transcription and Translation Organic cation transport RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 31036433 30929738) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Brain-derived neurotrophic factor levels ( 33345186) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) Gut microbiota alpha diversity (Chao1 index) ( 33208821) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 29146897 27182965 28196072) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Stroke ( 32693751) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		115 interacting genes: AKAP9 ATN1 CASK CCR6 CEP55 CRLF3 CTBP1 DDX17 DDX6 DMRTB1 DYNLT1 EP300 FMR1 FXR2 HNRNPK HOMER3 KHDRBS2 KIFAP3 KLC4 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NCOA6 NDEL1 NFKBID NR3C1 OGT PARD6G PARP1 PCBP1 PRKCI QKI RBM10 RBM5 RPA2 RUNX1 RUNX2 SLAIN1 SS18 SYT1 TARBP2 TRIM55 TRIM63 UBE2I XRCC5 YWHAE	76 interacting genes: AR BAG3 BAG4 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK6 CEBPA CEBPB COL6A1 COL6A2 COPRS CRYAA CSTB DNMT1 DTX2 DZIP3 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 GCC1 GSK3A HGS HIPK1 HIPK2 IKZF1 IKZF3 JUN KAT6A KAT6B MAPK1 MYOD1 NCOR1 NCOR2 NEDD4 NFKBID OLIG3 PAX5 PHTF1 PRMT1 PTPN12 PTTG1IP RBM14 RNF38 RNF44 SNRPC SPEN SPI1 SUV39H1 TAFAZZIN TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TNR TRIM5 UBE2L6 UHRF2 UXT VDR VPS37C WWP1 WWTR1 YAP1
Entrez ID		10432	861
HPRD ID		11485	01043
Ensembl ID		ENSG00000239306	ENSG00000159216
Uniprot IDs		A0A0S2Z4Z0 A0A0S2Z567 A0A0S2Z5V2 Q96PK6	Q01196
PDB IDs		2DNP	1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?
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