YAP1 and EIF3H

Number of citations of the paper that reports this interaction (PubMedID 32269044)
6

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical, imaging technique, enzymatic study, affinity chromatography technology)

		YAP1	EIF3H
Description		Yes1 associated transcriptional regulator	eukaryotic translation initiation factor 3 subunit H
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GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-YAP Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Polysomal Ribosome Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Metallopeptidase Activity Isopeptidase Activity Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Trophectodermal Cell Differentiation Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Cellular Response To DNA Damage Stimulus Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Wound Healing Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Development Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Asthma ( 29273806) Body mass index ( 25673413) Colorectal cancer ( 26965516 25990418 18372905 30529582 21761138 26151821 29471430 24737748) Colorectal cancer or advanced adenoma ( 30510241) Corneal curvature ( 22969067) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Ossification of the posterior longitudinal ligament of the spine ( 25064007) Right lateral prefrontal cortical growth ( 29682794) Systemic juvenile idiopathic arthritis ( 27927641) Waist circumference adjusted for body mass index ( 28552196 34021172)
Interacting Genes		37 interacting genes: ABL1 AKT1 CD28 EIF3H ENAH ERBB4 GAS5 HNRNPU KIF5A LINC00839 NFE2 OTUD1 PRRG2 PRRG4 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 USP10 WBP1 WBP2 YWHAG YWHAQ YWHAZ	15 interacting genes: ABI1 ABI2 ABI3 CCDC85B DISC1 EIF3G EIF3K LY6E NCK2 SNAI1 SORBS2 SORBS3 SPTBN1 UBC YAP1
Entrez ID		10413	8667
HPRD ID		09424	04885
Ensembl ID		ENSG00000137693	ENSG00000147677
Uniprot IDs		A0A024R3E4 K0KVU2 P46937 Q86T74	O15372 Q6IB98
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X	3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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