MYL9 and MYH9

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (two hybrid)

		MYL9	MYH9
Description		myosin light chain 9	myosin heavy chain 9
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Muscle Myosin Complex Cell Cortex Z Disc	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Brush Border Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Membrane Myosin II Complex Cell Leading Edge Neuromuscular Junction Cleavage Furrow Protein-containing Complex Actomyosin Cortical Granule Extracellular Exosome Myosin II Filament
	Molecular Function	Calcium Ion Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding	Microfilament Motor Activity RNA Binding Cytoskeletal Motor Activity Actin Binding Integrin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity ADP Binding Cadherin Binding Actin Filament Binding
	Biological Process	Regulation Of Muscle Contraction Platelet Aggregation	Meiotic Spindle Organization Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Plasma Membrane Repair Membrane Protein Ectodomain Proteolysis Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Lysosome Localization Cytokinetic Process Uropod Organization Blood Vessel Endothelial Cell Migration Regulated Exocytosis Leukocyte Migration Establishment Of Meiotic Spindle Localization Cortical Granule Exocytosis Platelet Aggregation Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Plasma Membrane Repair
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis Signaling by ALK fusions and activated point mutants
Drugs			Artenimol
Diseases
GWAS			Diabetic kidney disease ( 26305897) End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 30108283) Language performance in older adults (adjusted for episodic memory) ( 28577822) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Optic nerve measurement (rim area) ( 20395239) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		9 interacting genes: CDC42BPA CEP250 HSPB1 LRRK2 MSGN1 MYH9 PPP1R16B SLC12A5 TXN2	26 interacting genes: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 DUX4 FXR1 GRB2 GRIN1 MEN1 MTDH MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM UBE2I YWHAZ
Entrez ID		10398	4627
HPRD ID		17619	01177
Ensembl ID		ENSG00000101335	ENSG00000100345
Uniprot IDs		A0A384NY64 P24844	A0A024R1N1 P35579
PDB IDs			2LNK 3ZWH 4CFQ 4CFR 4ETO
Enriched GO Terms of Interacting Partners?
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