NDRG1 and TFAP2B

		NDRG1	TFAP2B
Description		N-myc downstream regulated 1	transcription factor AP-2 beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Microtubule Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Retina Layer Formation Magnesium Ion Homeostasis Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Hindlimb Morphogenesis Positive Regulation Of Urine Volume Aorta Morphogenesis Regulation Of Cell Population Proliferation Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Skin Development Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Anatomical Structure Development Regulation Of Insulin Secretion Phosphate Ion Homeostasis Calcium Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Distal Tubule Development Collecting Duct Development Metanephric Nephron Development Ductus Arteriosus Closure Cellular Ammonium Homeostasis Cellular Creatinine Homeostasis Cellular Urea Homeostasis
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Adiposity ( 19557161) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood urea nitrogen levels ( 31152163 29403010) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29381148 23563607 26961502 24861553 31453325 28892062 25673413 20935630 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005 26604143) Chronotype ( 30696823) Fruit consumption ( 32066663) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome (bivariate traits) ( 21386085) Myopia ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 21935397) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30054458 30297969 32499647) Urolithiasis ( 30975718) Waist circumference ( 31453325 25673412) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Walking pace ( 33128006)
Interacting Genes		72 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GPAA1 GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TFAP2B TLE3 UPF1 VCP XRCC5 ZNF155	16 interacting genes: AURKA CITED1 CITED2 CITED4 H2AC6 HCRTR2 LZTR1 MCM3 MYC NDRG1 SSBP4 SYT4 UBE2I VEGFA VPS11 YEATS4
Entrez ID		10397	7021
HPRD ID		05586	03360
Ensembl ID		ENSG00000104419	ENSG00000008196
Uniprot IDs		B3KWB2 Q8N959 Q92597	Q92481
PDB IDs		6ZMM
Enriched GO Terms of Interacting Partners?
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