PCGF3 and RING1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PCGF3	RING1
Description		polycomb group ring finger 3	ring finger protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Metal Ion Binding	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Inactivation Of X Chromosome By Genetic Imprinting	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 33169155) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Asthma ( 32296059) Wegener's granulomatosis ( 23740775)
Interacting Genes		11 interacting genes: BMI1 DZIP3 HNRNPK PHC1 PHC2 RING1 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3	37 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H2AC4 H3-4 NFKBID NSD1 OGT PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 PTEN RB1 RNF2 RYBP TP53 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K YAF2 ZIM3
Entrez ID		10336	6015
HPRD ID		11515	03624
Ensembl ID		ENSG00000185619	ENSG00000204227
Uniprot IDs		B3KQ06 B3KWT8 B4DTN5 Q3KNV8	A0A1U9X8F2 Q06587
PDB IDs
Enriched GO Terms of Interacting Partners?
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