MARCHF6 and DIO2

Number of citations of the paper that reports this interaction (PubMedID 19651899)
45

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		MARCHF6	DIO2
Description		membrane associated ring-CH-type finger 6	iodothyronine deiodinase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Enzyme Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity
	Biological Process	Proteasomal Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis
Pathways		ER Quality Control Compartment (ERQC)	Regulation of thyroid hormone activity
Drugs
Diseases
GWAS			Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)
Interacting Genes		10 interacting genes: ADGRE2 BUD31 DIO2 DNAH5 MTNR1B RGS2 TRIO UBC UBE2D2 UBE2G1	6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1
Entrez ID		10299	1734
HPRD ID		11095	09027
Ensembl ID		ENSG00000145495	ENSG00000211448
Uniprot IDs		O60337	A8K845 Q92813
PDB IDs
Enriched GO Terms of Interacting Partners?
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