CNKSR1 and CYTH1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CNKSR1	CYTH1
Description		connector enhancer of kinase suppressor of Ras 1	cytohesin 1
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity Establishment Of Epithelial Cell Polarity
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Intra-Golgi traffic
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Anxiety and major depressive disorder ( 24047446) Atrial fibrillation ( 30061737) HDL cholesterol levels ( 32203549) Pulse pressure ( 27841878 30578418) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878)
Interacting Genes		23 interacting genes: ARHGEF1 BRAP CADM4 CYTH1 CYTH2 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	16 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CCDC120 CNKSR1 CYTIP FOSL2 GNAQ INAVA IPCEF1 ITGB2 ITSN1 PRKCD SNAPC5 TRIM23
Entrez ID		10256	9267
HPRD ID		11937	01630
Ensembl ID		ENSG00000142675	ENSG00000108669
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	B7Z9W0 Q15438
PDB IDs		1WWV	1BC9 4A4P
Enriched GO Terms of Interacting Partners?
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