AP3S2 and E2F4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		AP3S2	E2F4
Description		adaptor related protein complex 3 subunit sigma 2	E2F transcription factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Axon Cytoplasm	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function		RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Intracellular Protein Transport Golgi To Vacuole Transport Anterograde Axonal Transport Vesicle-mediated Transport Anterograde Synaptic Vesicle Transport	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways			Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Type 2 diabetes ( 24509480 30054458 21874001 29358691 30297969 23945395 32499647 30718926 28869590) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2	32 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK DHX38 FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		10239	1874
HPRD ID		03880	02806
Ensembl ID		ENSG00000157823	ENSG00000205250
Uniprot IDs		A0A024RC62 P59780	Q16254
PDB IDs			1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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