TOPORS and UBE2J1

Number of citations of the paper that reports this interaction (PubMedID 19690564)
64

Data Source:
BioGRID (two hybrid)

		TOPORS	UBE2J1
Description		TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase	ubiquitin conjugating enzyme E2 J1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Nucleoplasm Centriole PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Nucleus Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity DNA Topoisomerase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	Protein Polyubiquitination Spermatid Development Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Early spontaneous preterm birth ( 31194736) Immune response to smallpox vaccine (IL-6) ( 22610502) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: CASP8 CREBBP EPM2A H2AX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SPOP SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W XRCC1	47 interacting genes: AQP2 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MFSD14B MFSD3 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC
Entrez ID		10210	51465
HPRD ID		11642	15599
Ensembl ID		ENSG00000197579	ENSG00000198833
Uniprot IDs		Q9NS56	Q9Y385
PDB IDs
Enriched GO Terms of Interacting Partners?
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