CDK4 and RAP2A

		CDK4	RAP2A
Description		cyclin dependent kinase 4	RAP2A, member of RAS oncogene family
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytosol Bicellular Tight Junction Mediator Complex Nuclear Membrane Perinuclear Region Of Cytoplasm Cyclin D2-CDK4 Complex	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein-containing Complex Binding Protein Serine Kinase Activity	Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Lens Development In Camera-type Eye Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Population Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Animal Organ Regeneration Cellular Response To Insulin Stimulus Response To Testosterone Regulation Of Multicellular Organism Growth Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Insulin Receptor Signaling Pathway Regulation Of Lipid Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Catalytic Activity Regulation Of Lipid Catabolic Process Cell Division Regulation Of Cell Cycle Response To Hyperoxia Regulation Of Transcription Initiation From RNA Polymerase II Promoter Adipose Tissue Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 30423114 24390342)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		148 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CA10 CAMK1 CAPN1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 CTDSP2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GNS GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AA1 IFI27 IFNG IGF1R IKZF3 IL15RA INCA1 IRF7 KDELR2 LATS2 LNX2 LUC7L2 LY75 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYC MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL OPTN ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RAP2A RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RNF139 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP15 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655	34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		1019	5911
HPRD ID		00447	01547
Ensembl ID		ENSG00000135446	ENSG00000125249
Uniprot IDs		A0A024RBB6 P11802	P10114
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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