TRIM28 and RFC4

Number of citations of the paper that reports this interaction (PubMedID 29955894)
8

Data Source:
BioGRID (pull down)

		TRIM28	RFC4
Description		tripartite motif containing 28	replication factor C subunit 4
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex Elg1 RFC-like Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Chromo Shadow Domain Binding Promoter-specific Chromatin Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition DNA Repair Chromatin Organization Ras Protein Signal Transduction Embryo Implantation Protein Ubiquitination Protein Sumoylation Positive Regulation Of Protein Import Into Nucleus DNA Methylation Involved In Embryo Development Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting	DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494)	Activated partial thromboplastin time ( 22703881)
Interacting Genes		79 interacting genes: CBX1 CBX3 CBX5 CDC34 CDC42 CDCA4 CDKN2A CEBPB CHAF1A CHD3 ESR1 FBP1 FES H4C1 HDAC10 HTRA2 IRF1 IRF7 LINC00624 LYN MAGEA2 MAGEA2B MAGEA6 MAGED1 MAPKAPK2 MCM3 MCM5 MCM6 MYB NPM1 NR3C1 NR4A1 NR4A3 NSMCE3 OGT PCNA PFDN5 PPP2CA PTEN RFC4 RNF4 SERTAD1 SERTAD2 SETDB1 SIN3A SIRT1 SKI SMARCAD1 SPG7 STAT3 SUMO2 TP73 TRIM24 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74 ZNF93	13 interacting genes: BRD4 CDK4 CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28
Entrez ID		10155	5984
HPRD ID		03445	00022
Ensembl ID		ENSG00000130726	ENSG00000163918
Uniprot IDs		Q13263	P35249
PDB IDs		1FP0 2RO1 2YVR 6H3A 6I9H 6QAJ 6QU1	6VVO
Enriched GO Terms of Interacting Partners?
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