AKAP9 and GPC4

Number of citations of the paper that reports this interaction (PubMedID 21516116)
114

Data Source:
BioGRID (two hybrid)

		AKAP9	GPC4
Description		A-kinase anchoring protein 9	glypican 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Potassium Channel Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle Dendritic Branch Synaptic Membrane Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Transmembrane Transporter Binding Molecular Adaptor Activity	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Microtubule Nucleation Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Chemical Synaptic Transmission Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein-containing Complex Localization Response To Electrical Stimulus Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization	Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF1 fusions AURKA Activation by TPX2	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		88 interacting genes: ABI2 ASB4 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GATAD1 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SGCE SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	11 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 MX1 PICK1 PTEN PTPRD PTPRF
Entrez ID		10142	2239
HPRD ID		04921	02160
Ensembl ID		ENSG00000127914	ENSG00000076716
Uniprot IDs		A0A0A0MRF6 Q5GIA7 Q6PJH3 Q99996	O75487
PDB IDs
Enriched GO Terms of Interacting Partners?
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