ACTR1A and SPTBN2

Number of citations of the paper that reports this interaction (PubMedID 11461920)
80

Data Source:
HPRD (in vivo)

		ACTR1A	SPTBN2
Description		actin related protein 1A	spectrin beta, non-erythrocytic 2
Image		No pdb structure
GO Annotations	Cellular Component	Manchette Cytoplasm Centrosome Centriole Cytosol Dynactin Complex Microtubule Associated Complex Microtubule Cytoskeleton COPI-coated Vesicle Extracellular Exosome Cell Cortex Region	Extracellular Space Cytosol Plasma Membrane Spectrin Apical Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Cell Projection Neuronal Cell Body Parallel Fiber To Purkinje Cell Synapse Presynapse Glutamatergic Synapse Postsynaptic Spectrin-associated Cytoskeleton
	Molecular Function	Protein Binding ATP Binding	Actin Binding Structural Constituent Of Cytoskeleton Phospholipid Binding Cadherin Binding Actin Filament Binding Structural Constituent Of Synapse
	Biological Process	Spermatogenesis Vesicle-mediated Transport	Cytoskeleton Organization Synapse Assembly Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Morphogenesis Actin Cytoskeleton Organization Adult Behavior Multicellular Organism Growth Actin Filament Capping Postsynapse Organization
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2	MHC class II antigen presentation NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 28115744 21926972 31043756) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder (MTAG) ( 33479212)
Interacting Genes		7 interacting genes: CNNM2 DCTN1 DCTN4 DPCD NUMA1 SPTBN1 SPTBN2	11 interacting genes: ACTA1 ACTB ACTR1A ADRB2 APC CELSR3 DCTN1 MINK1 SPTA1 SPTAN1 UNC13B
Entrez ID		10121	6712
HPRD ID		05507	05404
Ensembl ID		ENSG00000138107	ENSG00000173898
Uniprot IDs		A0A384NQ21 P61163	O15020
PDB IDs			1WJM 1WYQ 6ANU
Enriched GO Terms of Interacting Partners?
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