FEM1B and TLE3

		FEM1B	TLE3
Description		fem-1 homolog B	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Death Receptor Binding Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways		Neddylation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033 32439900) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APAF1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A TLE3	24 interacting genes: APP BIRC5 BMP3 CHERP CSTF2 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 RPL4 SIX1 SIX2 SIX3 SRP14 TAOK2 TCF7L2 XIAP
Entrez ID		10116	7090
HPRD ID		16889	02558
Ensembl ID		ENSG00000169018	ENSG00000140332
Uniprot IDs		Q9UK73	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs		6LBF 7CNG
Enriched GO Terms of Interacting Partners?
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