HDAC6 and HTATSF1

Number of citations of the paper that reports this interaction (PubMedID 21220424)
36

Data Source:
BioGRID (pull down)

		HDAC6	HTATSF1
Description		histone deacetylase 6	HIV-1 Tat specific factor 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Cytosol Microtubule Microtubule Associated Complex Caveola Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm Axon Cytoplasm	Nucleus Nucleoplasm U2-type Spliceosomal Complex U2 SnRNP
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding	RNA Binding
	Biological Process	Protein Polyubiquitination Protein Deacetylation Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Negative Regulation Of Microtubule Depolymerization Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Macroautophagy Histone Deacetylation Axonal Transport Of Mitochondrion Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Protein-containing Complex Disassembly Positive Regulation Of Peptidyl-serine Phosphorylation Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Collateral Sprouting Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Cellular Response To Misfolded Protein Tubulin Deacetylation Polyamine Deacetylation Spermidine Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Signaling Receptor Activity	MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Viral Genome Replication Regulation Of DNA-templated Transcription, Elongation
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cilium Assembly Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs		Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Bufexamac
Diseases
GWAS
Interacting Genes		86 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CSF3 CSNK2A2 CTTN CYLD DYNLL2 EGFR EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H3C1 H4-16 HDAC11 HES1 HSP90AA1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MSH2 NACAD NASP NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF31 RUNX2 SEPTIN7 SIRT2 SYK TPPP TRIM50 TUBA1A TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 YWHAZ ZBTB16 ZNF205	20 interacting genes: APBB1 CCNT1 CDK9 CLK1 CSNK2A1 ERCC6 FEZ1 GTF2F2 HDAC6 POLR2A SF3A2 SNRNP70 SNRPB2 SRPK2 SRSF4 SUPT4H1 SUPT5H THAP1 WBP4 ZNF512B
Entrez ID		10013	27336
HPRD ID		02228	02282
Ensembl ID		ENSG00000094631	ENSG00000102241
Uniprot IDs		A0A024QZ26 B4DZH6 Q9BRX7 Q9NSW6 Q9UBN7	O43719
PDB IDs		3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF	2DIT 6N3D 6N3E 6N3F 6NSX 6Y50 6Y53 6Y5Q
Enriched GO Terms of Interacting Partners?
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