ADA and ADORA2B

Number of citations of the paper that reports this interaction (PubMedID 11125033)
24

Data Source:
HPRD (in vivo, in vitro)

		ADA	ADORA2B
Description		adenosine deaminase	adenosine A2b receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Vesicle Lumen	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding 2'-deoxyadenosine Deaminase Activity	G Protein-coupled Adenosine Receptor Activity Protein Binding
	Biological Process	Allantoin Metabolic Process Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process AMP Catabolic Process Cell Adhesion Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion	G Protein-coupled Adenosine Receptor Signaling Pathway Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion
Pathways		Purine salvage	Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production
Drugs		Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE	Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Serum metabolite levels ( 33031748) Ulcerative colitis ( 28067908 23128233)	HDL cholesterol levels in HIV infection ( 33109212) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		12 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2 WFDC12	7 interacting genes: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267
Entrez ID		100	136
HPRD ID		00038	15971
Ensembl ID		ENSG00000196839	ENSG00000170425
Uniprot IDs		A0A0S2Z381 F5GWI4 P00813	P29275
PDB IDs		1M7M 3IAR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?