TRIM41 and PRKCA

Data Source:
BioGRID (pull down)

		TRIM41	PRKCA
Description		tripartite motif containing 41	protein kinase C alpha
Image
GO Annotations	Cellular Component	Nucleolus Cytoplasm Nuclear Body	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Mitochondrial Membrane Alphav-beta3 Integrin-PKCalpha Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Integrin Binding Protein Binding ATP Binding Zinc Ion Binding Enzyme Binding Histone Kinase Activity (H3-T6 Specific)
	Biological Process	Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Desmosome Assembly Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Platelet Activation Positive Regulation Of Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Histone H3-T6 Phosphorylation Intracellular Signal Transduction ERBB2 Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Bone Resorption Positive Regulation Of Cell Adhesion Positive Regulation Of Mitotic Cell Cycle Regulation Of Insulin Secretion Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Calmodulin induced events Disinhibition of SNARE formation SHC1 events in ERBB2 signaling Signaling by SCF-KIT Regulation of KIT signaling EGFR Transactivation by Gastrin Inactivation, recovery and regulation of the phototransduction cascade Syndecan interactions Acetylcholine regulates insulin secretion Ca2+ pathway Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina HuR (ELAVL1) binds and stabilizes mRNA WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RET signaling ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
Drugs			Phosphatidyl serine Vitamin E Tamoxifen Ingenol mebutate Aprinocarsen Midostaurin Perifosine Ellagic acid Bryostatin 1 alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS			Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Cardiorespiratory fitness (800m run time) ( 32572135) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery calcification ( 23870195) Cryptosporidiosis ( 32019797) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Food addiction ( 27106561) Gout ( 22179738) Height ( 22021425) Heschl's gyrus morphology ( 25130324) Lateral occipital cortex volume ( 31530798) Neuroticism ( 29255261) Percent glycated albumin ( 29844224) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) PR interval ( 32439900) QRS complex (12-leadsum) ( 27659466) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 30012220 27659466) QT interval ( 29213071 24952745 29874175) Systolic blood pressure ( 31170924) Total glycated albumin levels ( 29844224)
Interacting Genes		140 interacting genes: AEN AKTIP ANKRD23 AP1M1 APP AQP1 BIVM BRAP BYSL C8orf33 CARD10 CCNL2 CEP44 CHD2 CSNK2A1 CSNK2A2 DEPTOR DVL3 EHHADH EZHIP FAM124A FAM161A FAM9A FLACC1 FRA10AC1 GAS8 GPATCH2L IKBKG JRK KATNBL1 KIFC3 KRTAP10-8 KRTAP10-9 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MID2 MOBP MORF4L1 MORF4L2 MPP3 NCK2 NEDD4L NOD2 PBX4 PHC2 PHF11 PHF7 PLAGL2 PRDM14 PRKCA PRKCB PRPF31 PTPN3 PUS7L RBAK RNPS1 SORBS3 SRPK2 STX11 SUV39H1 SYCE1 SYTL4 TBC1D26 TCEA2 TCEANC TLE5 TNNI1 TOP3B TRAIP TRIM17 TRIM26 TRIM4 TRIM52 TRIM55 TRIM63 UBE2D2 UBE2I ZBTB24 ZBTB26 ZBTB38 ZBTB39 ZBTB48 ZBTB8A ZCCHC7 ZFP1 ZFP2 ZFP64 ZMAT5 ZNF121 ZNF134 ZNF138 ZNF165 ZNF2 ZNF219 ZNF24 ZNF250 ZNF251 ZNF26 ZNF263 ZNF264 ZNF266 ZNF275 ZNF286A ZNF319 ZNF329 ZNF343 ZNF398 ZNF408 ZNF417 ZNF439 ZNF460 ZNF473 ZNF48 ZNF490 ZNF497 ZNF526 ZNF552 ZNF564 ZNF575 ZNF587 ZNF629 ZNF648 ZNF653 ZNF655 ZNF670 ZNF691 ZNF696 ZNF71 ZNF773 ZNF780A ZNF784 ZNF792 ZNF835 ZNF837 ZSCAN16 ZSCAN21 ZSCAN26	228 interacting genes: ACTA1 ADAP1 ADCY5 ADD1 ADD3 ADRA1B AFAP1 AKAP12 AKAP5 ANXA2 ANXA7 APLP2 ARHGEF1 ATP1A1 ATP2B1 ATP2B2 AVPR1A BCL2 BTG2 BTK C1QBP CACYBP CASR CAVIN2 CBL CD163 CD5 CD9 CDC42 CDKN2A CFTR CHAT CISH CORO1B CREM CYP3A4 CYTH2 DDX5 DGKD DGKZ DLG4 DLX3 DNM1 DVL2 EDF1 EEF1D EGFR EGLN2 EIF2S1 EIF4E EIF4EBP1 ELAVL1 ENTPD5 EP300 EWSR1 EZR F11R FAS FBXO25 FBXO7 FCGR2B FCGR3A FLNA FLNC FSCN1 GABRB3 GABRG2 GABRR1 GABRR2 GFAP GFPT1 GJA1 GJB1 GLI3 GMFB GNA12 GNA15 GPM6A GRIA1 GRIA2 GRIA4 GRIN1 GRIN2A GRIN2B GRK2 GRM1 GRM5 GSK3A GSK3B H1-1 H1-2 H1-3 H1-4 H1-5 H1-6 H3-4 H3C1 HABP4 HAND1 HAND2 HES1 HLA-A HMGA1 HMGA2 HMGB1 HMGN1 HMGN2 HR HSP90AA1 HSPA1A HSPB8 IKBKB INSR ITGB1 ITGB2 ITGB4 ITPKA ITPKB KCNE1 KCNE4 KCNQ2 KIT KLF5 KRT18 LCK LMNA LMNB1 MAPKAP1 MAPT MARCKS MBP MGMT MTOR MYLK MYOD1 NCF1 NF2 NFATC1 NFE2L2 NFKBIA NOS1 NOXA1 NR1H2 NRGN NUMB OGG1 OPRD1 PA2G4 PAM PDLIM7 PEA15 PEBP1 PFKFB1 PFKFB2 PHB2 PICK1 PLA2G4A PLCB1 PLD1 PLD2 POLB PPARA PPARG PPM1A PPP1R14A PRKCZ PRKG1 PSMB4 PTGIR PTPN11 PTPN12 PTPN6 RAC1 RACK1 RAF1 RALBP1 RARA RBCK1 RGS19 RGS2 RGS7 RHO RHOA RNF31 RPL10 RRAD SACM1L SCRIB SCTR SDC2 SDC4 SELL SEMG1 SEMG2 SHC1 SLC1A1 SLC6A9 SLC9A3R1 SLC9A3R2 SMURF1 SNAP23 SNAP25 SPAG1 SPP1 SRC STXBP1 STXBP3 SYK TBXA2R TEP1 TERT THOC5 TIAM1 TNNI3 TNNT2 TNP1 TNP2 TOP2A TP53 TRIM29 TRIM41 TRPC3 TRPV6 VCL VTN XK YWHAG YWHAZ
Entrez ID		90933	5578
HPRD ID		15558	01498
Ensembl ID		ENSG00000146063	ENSG00000154229
Uniprot IDs		Q8WV44	L7RSM7 P17252 Q7Z727
PDB IDs		2EGM	2ELI 3IW4 4DNL 4RA4
Enriched GO Terms of Interacting Partners?
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