KRTAP4-4 and CBX2

Data Source:
BioGRID (two hybrid)

		KRTAP4-4	CBX2
Description		keratin associated protein 4-4	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		Keratinization	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		67 interacting genes: ADAMTSL4 ALX1 AQP1 BAG4 CATSPER1 CBX2 CRCT1 CREB5 CYSRT1 GLRX3 GNE HEY2 HOXA1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-5 KRTAP10-6 KRTAP10-8 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-11 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3E LCE4A LCE5A MEOX2 NBPF19 NOTCH2NLA NPDC1 NR4A3 NUFIP2 OTX1 POU4F2 SHFL SMCP TNS2 TRIM42 ZNF440 ZNF497 ZNF764	25 interacting genes: BOLL CYSRT1 DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 PCGF2 PHC2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RNF2 RYBP TRIM55 TRIM63
Entrez ID		84616	84733
HPRD ID		13945	14397
Ensembl ID		ENSG00000171396	ENSG00000173894
Uniprot IDs		Q9BYR3	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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