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H2AC4 and KAT5
Data Source:
BioGRID
(enzymatic study)
H2AC4
KAT5
Description
H2A clustered histone 4
lysine acetyltransferase 5
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Exosome
Swr1 Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Piccolo NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Transcription Coregulator Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Acetyltransferase Activity
Histone Binding
Metal Ion Binding
Peptide-lysine-N-acetyltransferase Activity
Repressing Transcription Factor Binding
Biological Process
Chromatin Silencing
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
DNA Double-strand Break Processing
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Ionizing Radiation
Positive Regulation Of Autophagy
Viral Process
Histone Acetylation
Protein Phosphopantetheinylation
Peptidyl-lysine Acetylation
Negative Regulation Of Interleukin-2 Production
Regulation Of Growth
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Acetylation
Beta-catenin-TCF Complex Assembly
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
DNA Damage/Telomere Stress Induced Senescence
HATs acetylate histones
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Estrogen-dependent gene expression
Drugs
Coenzyme A
S-Acetyl-Cysteine
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Chronic kidney disease (
20383146
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate (
31152163
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
32203549
28334899
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Triglyceride levels (
32203549
)
Triglycerides (
30275531
)
Interacting Genes
25 interacting genes:
BAP1
BMI1
BRCA1
CDK1
CDK2
EIF2AK2
EP300
FANCD2
H2BC15
H2BC3
KAT2B
KAT5
MAP4K1
MYB
PRMT5
PSMD4
PTEN
RNF168
RNF2
RPL6
TRIM37
UBE2D3
UHRF1
USP16
USP51
191 interacting genes:
AGO2
ALOX12
ALX1
ANTKMT
APBB1
APLP1
APLP2
APP
AR
ARIH2
ATF3
ATM
ATXN1
BACH2
BARD1
BCL3
BLZF1
BMI1
BRCA1
C1orf131
C1orf174
CAVIN1
CBX8
CCDC106
CCDC125
CCDC136
CCNB1
CCT7
CDC42
CDK1
CDK5RAP2
CDKN2A
CEP126
CEP70
CREB1
CREBBP
CRELD1
CSTF2
DLEU1
DNAAF6
DUSP23
E2F1
E2F4
EDNRA
EFNA1
EP300
EP400
EPC1
ESR1
ESR2
ETV6
FAM135B
FAM161A
FCHO1
GADD45G
GAPDH
GEMIN7
GET4
GIGYF1
GKAP1
GMCL1
GMCL2
GOLGA2
GSTO1
GTF2E2
H2AC20
H2AC4
H2AX
H3-3B
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
HABP4
HAP1
HDAC1
HDAC7
HMBOX1
HNRNPH3
HSF2BP
ID3
IFT20
IK
IKZF3
IL9R
KCTD7
KLF4
KPNA3
KPNA4
KPNA5
KPNA6
KRT40
KRTAP10-3
KRTAP10-9
LMNA
LONRF1
LRIF1
LRP1
LZTS1
LZTS2
MAD2L1BP
MAPRE1
MCC
MCPH1
MDFI
MDM2
MEOX2
MTUS2
MYC
MYOD1
NAP1L5
NDUFA4L2
NDUFV2
NFKB1
NINL
NR3C1
ODC1
OGFOD2
PDCD5
PFKP
PHC2
PICK1
PITX2
PLA2G4A
PLEKHA4
PML
POLE2
POLR3F
PPARG
PPP1R16A
PRDM6
PROSER2
PTPN4
PTPRS
RB1
RCHY1
RELA
RFLNB
RGL2
RRM2
SAT1
SCRN2
SERTAD2
SHISA6
SNAPIN
SNRPD2
SOX5
SPATA2
SQSTM1
SRF
SRSF2
SSX2IP
STAT3
STMN3
STX11
SYCE1
SYN1
TAX1BP1
TBX5
TELO2
TFIP11
TMCC2
TNNT1
TP53
TRIB3
TRIM23
TRIM27
TRIM29
TRIM37
TUFT1
UBASH3B
UHRF1
UPRT
USP7
YJU2
YWHAG
ZBTB1
ZBTB14
ZBTB2
ZBTB8A
ZC2HC1C
ZEB1
ZNF24
ZNF417
ZNF511
ZNF513
ZNF526
ZNF692
ZSCAN4
Entrez ID
8335
10524
HPRD ID
09105
03245
Ensembl ID
ENSG00000278463
ENSG00000172977
Uniprot IDs
P04908
Q08AJ9
A0A024R597
A0A024R5E8
Q92993
PDB IDs
2CV5
2RVQ
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3W96
3W97
3W98
3W99
3WKJ
3WTP
3X1S
3X1V
4YM5
4YM6
4Z5T
5AV5
5AV6
5AV8
5AV9
5AVB
5AVC
5AY8
5B0Y
5B0Z
5B24
5B2I
5B2J
5B31
5B32
5B40
5CPI
5CPJ
5CPK
5GSE
5GTC
5GXQ
5JRG
5X7X
5XF3
5XF4
5XF5
5Y0C
5Y0D
5Z23
5ZBX
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6ACL
6AEE
6BUZ
6E0C
6E0P
6HKT
6HTS
6INQ
6IPU
6IQ4
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6JR0
6JR1
6JXD
6KE9
6KXV
6L49
6L4A
6L9H
6LA8
6LA9
6LE9
6M3V
6M44
6O1D
6R8Y
6R8Z
6R90
6R91
6R92
6R93
6R94
6T79
6T7A
6T7B
6T7C
6T7D
6T90
6T93
6V92
6YOV
7C0M
7CCQ
7CCR
2EKO
2OU2
4QQG
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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