SHARPIN and KRTAP7-1

Data Source:
BioGRID (two hybrid)

		SHARPIN	KRTAP7-1
Description		SHANK associated RH domain interactor	keratin associated protein 7-1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex	Intermediate Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Protein Binding
	Biological Process	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		21 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	37 interacting genes: ARID5A C11orf16 C1orf94 CELF5 CREB5 CRYBA2 DTX2 FAM168A FOXH1 GATA2 GCM2 HGS HNRNPF MKRN3 MYOZ3 OTX1 PITX1 PITX2 PRR13 PSMB1 RANBP3 RHOXF2 RNF38 ROR2 SHARPIN SMARCC1 SNRPC SPAG8 TCF7L2 TEKT4 TFAP2D TLE5 TLX3 TOLLIP VPS37C YTHDF1 ZIC1
Entrez ID		81858	337878
HPRD ID		15463	19546
Ensembl ID		ENSG00000179526	ENSG00000274749
Uniprot IDs		Q6PJD5 Q9H0F6	Q8IUC3
PDB IDs		4EMO 5X0W
Enriched GO Terms of Interacting Partners?
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